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[摘要]：The mechanism of hepatitis E virus (HEY) replication remains largely unknown. Here we demonstrate that HEV replication requires an active ubiquitin-proteasome system and that proteasome inhibitors affect HEY replication, possibly by inhibition of viral transcription or/and translation without a significant effect on cellular translation. Overexpression of ubiquitin in inhibitor-treated cells partially reverses the inhibitor effect on HEY replication. The results suggest that HEY replication requires interactions with proteasome machinery, which could be a potential therapeutic target against HEY. |
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