Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides

[摘要]：Regiospecifically sulfated chondroitin sulfate repeating tetrasaccharides, CS-OO, GlcA beta-GalNAc beta-GlcA beta-GalNAc beta; CS-EE, GlcA beta-GalNAc(4S6S)beta-GlcA beta-GalNAc(4S6S)beta; and CS-AA, GlcA beta-GalNAc(4S)beta-GlcA beta-GalNAc(4S) beta, having biotin linked with a hydrophilic linker at the reducing terminal were synthesized effectively by a coupling of the corresponding disaccharide units and regioselective sulfation. CS-EE showed greater affinity for midkine than CS-AA and CS-OO. (C) 2011 Elsevier Ltd. All rights reserved.

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