Cytotoxic Evaluation of Pungencine: A New Tropane Alkaloid from the Roots of Erythroxylum pungens O. E. SCHULZ

[摘要]：A new tropane alkaloid as well as a new substitution group, (3-endo,8-anti)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 4-hydroxy-3,5-dimethoxybenzoate, called pungencine (1), was isolated from the roots of Erythroxylum pungens O. E. SCHULZ. The structure was elucidated by spectral analyses. including H-1- and C-13-NMR and 2D-NMR techniques (H-1.H-1-COSY, NOESY, DEPT, HMQC, and HMBC) and HR-ESI-MS. Furthermore, compound I was tested for cytotoxicity against several cell lines (Jurkat, HL-60, U937, K562, KG-1, and U266) and was determined not to inhibit cell viability it 10 mu M.

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