【文章名】Polymorphic variability in the interleukin (IL)-1 beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1 beta production
Polymorphic variability in the interleukin (IL)-1 beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1 beta production
[摘要]：Interleukin (IL)-1 beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1 beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1 beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level < 6.0 g/dL), and circulating IL-1 beta levels were investigated in children with parasitemia (n = 566) from western Kenya. The IL-1 beta promoter haplotype -31C/-511A ( CA) was associated with increased risk of SMA (Hb level < 6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P <. 05) and reduced circulating IL-1 beta levels (P <.05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA ( OR, 0.52 [95% CI, 0.18-1.16]; P=.11) and elevated IL-1 beta production (P <.05). Compared with the non-SMA group, children with SMA had significantly lower IL-1 beta levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1 beta. The results presented demonstrate that variation in IL-1 beta promoter conditions susceptibility to SMA and functional changes in circulating IL-1 beta levels.
