Addition of Purines to N-Boc Imines Generated in Situ in Water: Efficient Synthesis of Novel Acyclic Purine Azanucleosides

[摘要]：A mild, efficient and highly regioselective addition of purine derivatives to N-Boc imines generated in situ in water was developed for the first time. A wide range of novel acyclic purine azanucleosides were synthesized in moderate to high yields through this transformation. This methodology was also appropriate for some other N-heterocycles.

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