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[摘要]：The whole plants of Carpesium divaricatum are used in traditional medicine as an antipyretic, analgesic and vermifugic, including a topical application for sores and inflammation. In a previous paper, the isolation and structural elucidation of isolated ineupatorolides A from methanol extracts of C. rosulatum (Compositae) were reported. The present paper deals with the isolation and identification of antiplasmodial compounds from C divaricatum in Carpesium spp. Five compounds., 1 beta,6 alpha-dihydroxy-4(15)-eudesmene [1], beta-dictyopterol [2], 2-isopropenyl-6-acetyl-8-methoxy-1,3-benzodioxin-4-one [3],(3E,6E,10E,14E,18E)-2,6,1(1,15,19,23-hexamethyl-3,6,10,14,18,22-tetracosahexaen-2-oI [41 and neophytadiene 15], were isolated from the whole plants of C. divaricatum. The in vitro activity against P. falciparum strain D10 was assessed using the parasite lactate dehydrogenase assay method. The main antiplasmodial principle, 2-isopropenyl-6-acetyl-8-methoxy-1,3-benzodioxin-one [31, has been isolated front C divaricatum for the first time. Compound 3 exhibited in antiplasmodial activity with IC50 values of 2.3 +/- 0.3 mu M. This is the first report on the antiplasmodial activity, of the compounds from C. divaricatum. Copyright (C) 2009 John Wiley & Sons, Ltd. |
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