Base-Catalyzed Conjugate Addition of Thiols to Indolyl Acrylic Acids and in situ Decarboxylation: An Expedient Synthesis of Functionalized 3-(1-Thio)ethyl-1H-indoles

[摘要]：A one-pot, two-step method for the synthesis of 3-(1-thio)ethyl-1H-indoles is described herein. This simple procedure involves the Michael addition of thiols to 3-indoleacrylic acids followed by in situ decarboxylation of the Michael adduct in the presence of a catalytic amount of K2CO3 in DMF at 100 degrees C. The method was found to be fairly general with various thiols and different 3-indoleacrylic acids.

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