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Enantioselective Organocatalytic Conjugate Addition of Aromatic Ketones to Nitrodienes

  作者 HE TIANXIONG; QIAN JINGYING; SONG HONGLIANG; WU XINYAN  
  选自 期刊  SYNLETT;  卷期  2009年-19;  页码  3195-3197  
  关联知识点  
 

[摘要]The organocatalytic asymmetric nitro-Michael addition of aromatic ketones to nitrodiene using various chiral primary amine thioureas was described. In the presence of 30 mol% of N-[(1R,2R)-2-amino-1,2-diphenylethyl]-N'-benzylthiourea, the Michael adducts were obtained in good yields and excellent enantioselectivity (94-98% ee).

 
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