Total Synthesis of (+)-Cardiobutanolide through a Carbohydrate-Based Approach

[摘要]：The naturally occurring styryllactone (+)-cardiobutanolide has been synthesized in a highly efficient manner using D-glucono-delta-lactone, as a chiral pool starting material. The synthesis involves the stereoselective addition of Grignard reagent to a chiral aldehyde, zinc-mediated reductive deoxygenation of 4-alkoxybut-2-enoic acid moiety and asymmetric dihydroxylation as the key steps.

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