[摘要]：An efficient methodol. for the nucleophilic fluoromethylation of alkyl and benzyl halides using a-fluoro-a-(phenylsulfonyl)methane as a highly versatile reagent is reported. Using benzyl halides, stereospecific one-pot synthesis of a-fluorovinyl compds. such as a-fluorostyrylsulfones, a-fluorocinnamates, and a-fluorochalcones has been achieved. The methodol. has been extended toward the synthesis of a-substituted fluoroalkane derivs. using selective reductive desulfonylation conditions.
