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PHLOROGLUCINOLS FROM THE LEAVES OF EUCALYPTUS GLOBULUS

  作者 KAWABATA TETSURO; HASEGAWA TATSUYA; NOJIRI YUKA; UCHIDA CHIAKI; TSUBATA TOMOYUKI; KATO HIKARU; TAKANO FUMIHIDE; OHTA TOMIHISA  
  选自 期刊  Heterocycles;  卷期  2011年83-3;  页码  631-636  
  关联知识点  
 

[摘要]A new acylphloroglucinol sesquiterpene structure, euglobal-IX (1), together with five known compounds, euglobal-III (2), -IVa (3), -IVb (4), -Ia(2) (5) and robustadial B (6), were isolated from the leaves of Eucalyptus globulus extracted with methanol or methanolic ethylacetate. The chemical structure and relative configuration of 1 was determined by ID, 2D NMR and MS spectroscopic analyses. New acylphloroglucinol 1 inhibited the catalytic activity of CYP3A4 (IC50 = 38.8 mu M).

 
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