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Aziridine-2-carboxaldehyde Dimers Undergo Homo-Ugi 4-Component-5-center Reactions

  作者 ROTSTEIN BENJAMIN H; YUDIN ANDREI K  
  选自 期刊  Synthesis;  卷期  2012年44-18;  页码  2851-2858  
  关联知识点  
 

[摘要]Dimeric alpha-aziridine aldehydes have been used as the aldehyde component in Ugi and Passerini reactions. The highly reactive mixed anhydride intermediate is subject to nucleophilic attack by the aziridine, leading to 'homo-Ugi' beta-acylaziridinyl-alpha-amino-amides. The products can be readily transformed into substituted lactones.

 
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