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[摘要]：A new type of Thermo- and pH-responsive homopolymer was synthesized using reversible addition fragmentation chain transfer (RAFT) polymerization. A novel functional methacrylamide monomer bearing alpha-aspartic acid derivative in the side chain, i.e., N-methacryloyl-L-beta-isopropylasparagine benzyl ester (MA-iAsn-OBen), was first synthesized. Three poly(N-methacryloyl-L-beta-isopropylasparagine benzyl ester)s [poly(MA-iAsn-OBen)] with controllable molecular weight and narrow molecular weight distribution were then prepared using RAFT polymerization. Selective removal of benzyl groups produced poly(N-methacryloyl-L-beta-isopropylasparagine) [poly(MA-iAsn-OH)]. which displayed a reversible lower critical solution temperature (LCST) in water. In addition, the LCST can be adjusted from 29 to 60 degrees C by changing solution pH values, salt concentrations, and polymer molecular weights. Using macromolecular chain transfer agent and RAFT polymerization, we prepared well-defined amphiphilic mPEG(45)-b-poly(MA-iAsn-OBen)(53) diblock copolymer and double hydrophilic block copolymer [mPEG(45)-b-poly(MA-iAsn-OH)(53)]. The latter showed a thermo-induced self-assembly in water due to collapse of poly(MA-iAsn-OH) segment. We found that mPEG(45)-b-poly(MA-iAsn-OH)(53), was soluble at room temperature while formed vesicles above the LCST of poly(MA-iAsn-OH)(53). |
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