Synthesis of 2-Thio-Substituted-Benzothiazoles via a Domino Condensation/S-Arylation/Heterocyclization Process

[摘要]：Condensation of carbon disulfide with thiols in the presence of K2CO3 generates carbonotrithioate salts in situ, which undergo coupling with 2-iodoanilines and subsequent intramolecular condensation and elimination under assistance of CuBr to afford 2-thio-substituted benzothiazoles. Both aliphatic and aromatic thiols are compatible with this process, delivering the corresponding heterocycles with good diversity.

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