Resolution of Carboxylic Acids Using Copper(I)-Promoted Removal of Propargylic Esters under Neutral Conditions

[摘要]：A method for the optical resolution of carboxylic acids is described. Condensation of racemic carboxylic adds with chiral terminal propargyl alcohols gave separable diastereomeric esters. Chromatographic separation followed by heating the individual diastereomers in methanol with catalytic copper(I) halide regenerated the carboxylic adds in good yields and in enantiomeric ratios of >= 94%. This method is particularly useful for the resolution of carboxylic acids that are incompatible with conventional ester hydrolysis.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内