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Nucleosomes Suppress Spontaneous Mutations Base-Specifically in Eukaryotes

  作者 Chen, XS; Chen, ZD; Chen, H; Su, ZJ; Yang, JF; Lin, FQ; Shi, SH; He, XL  
  选自 期刊  Science;  卷期  2012年335-6073;  页码  1235-1238  
  关联知识点  
 

[摘要]It is unknown how the composition and structure of DNA within the cell affect spontaneous mutations. Theory suggests that in eukaryotic genomes, nucleosomal DNA undergoes fewer C -> T mutations because of suppressed cytosine hydrolytic deamination relativ

 
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