Synthesis and Biological Evaluation of Novel 2-(4-o-beta-D-Glucosidoxyphenyl)-4,5-disubstituted Imidazoles

[摘要]：A series of 2-(4-hydroxyphenyl)-4,5-disubstituted imidazoles (la-e) prepared from alpha-diketones, ammonium acetate, and p-hydroxybenzaldehyde, which were glucosylated by using alpha-acetobromoglucose to form 2-(4-o-beta-D-2,3,4,6-tetra-o-acetyl-glucosidoxyphenyl)-4,5-disubstitut ed imidazoles (2a-e) which on catalytic deacetylation with CH3ONa in methanol afforded the title compound 2-(4-o-beta-D-glucosidoxyphenyl)-4,5-disubstituted imidazoles (3a-e). Compounds were characterized by elemental analysis and by instrumental technique, similarly the title compounds were investigated for antimicrobial and antifunctal activity.

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