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An Efficient One-Pot Synthesis of N-(1,3-Diphenyl-1H-Pyrazol-5-yl)amides

  作者 SU WEINIEN; LIN TSUNGPING; CHENG KAUNGMIN; SUNG KUANCHIN; LIN SHAOKAI; WONG FUNG FUH  
  选自 期刊  Journal of Heterocyclic Chemistry;  卷期  2010年47-4;  页码  831-837  
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[摘要]A "one-pot" method for the synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides was developed by cyclization of benzoylacetonitrile (1) and phenylhydrazine in neat condition followed by acylation. The corresponding N-(1,3-diphenyl-1H-pyrazol-5-yl)amides were provided in good to excellent yields (70 90%). The significant advantages of the new synthetic method are excellent yields and simple work-up procedure without isolation and purification of intermediary 5-amino-1,3-diphenyl pyrazol (2).

 
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