Studies Toward the Synthesis of Spirolides: Assembly of the Elaborated E-Ring Fragment.

[摘要]：A stereoselective synthesis of the spiroimine fragment of spirolide C is described by prepg. the advanced intermediate I. The congested C7 and C29 tertiary and quaternary centers are constructed by a diastereoselective Ireland-Claisen rearrangement. The E ring is completed by means of an aldol cyclocondensation. Addnl. studies were preformed on the advanced intermediate to probe a future coupling strategy.

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