Asymmetric Synthesis of the C14-C26 Building Block of Eribulin Mesylate

[摘要]：An alternative route for the synthesis of the C14-C26 building block of the anticancer drug eribulin mesylate is described. The key steps involved in the synthesis are a Julia-Kocienski olefination between aldehyde 4 and sulfone 5 and a tandem Sharpless asymmetric dihydroxylation/S(N)2 cyclisation reaction on mesyl compound 3.

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