Chiral N-(coumarin-3-ylcarbonyl)-a-amino acids: fluorescent markers for amino acids and dipeptides.

[摘要]：N-(Coumarin-3-ylcarbonyl)benzotriazole has been coupled with free amino acids, N-terminal-protected lysines and dipeptides to afford fluorescent amino acids and dipeptides (76-89% yield) with retention of original chirality. Na- and Ne-Coumarin labeled lysines are obtained by simple, two-step procedures. Na-Cbz-Ne-(Coumarin-3-ylcarbonyl)-L-lysine is demonstrated to be an optically active fluorescent marker for labeling amino acids in soln.-phase syntheses.

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