A novel and efficient synthesis of 1-hydroxyquinazolin-4-ones via tin(II) chloride induced cyclization of 2-nitrobenzamides and ketones.

[摘要]：A mild, efficient, and novel synthesis of 2,3-dihydro-1-hydroxyquinazolin-4(1H)-ones via cyclization of 2-nitrobenzamides and ketones induced by SnCl2.2H2O is described. This new method has the advantages of accessible starting materials, convenient manipulation, short reaction times, and high yields.

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