Formal Syntheses of Naturally Occurring Welwitindolinones

[摘要]：The formal syntheses of N-methylwelwitindolinone C isothiocyanate, N-methylwelwitindolinone C isonitrile, N-methylwelwitindolinone D isonitrile, 3-hydroxy-N-methylwelwitindolinone C isothiocyanate, and 3-hydroxy-N-methylwelwitindolinone C isonitrile are reported. The synthesis features several novel processes, Including a Lewis acid mediated coupling between a benzylic-type heteroaromatic alcohol and a highly functionalized silyl ketene acetal, an intramolecular enolate arylation, and a regioselective, Pd(0)-catalyzed pi-allylic cyclization of a gamma-benzoyloxy enone moiety that is revealed by unmasking a furan ring.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内