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Three-Component, One-Pot Sequential Synthesis of Tetracyclic Pyrido[2 ',1 ':2,3]imidazo[5,1-a]isoquinolinium Compounds as Potent Anticancer Agents

  作者 ZHOU HUAYONG; WANG WEI; KHOREV OLEG; ZHANG YONGLIANG; MIAO ZEHONG; MENG TAO; SHEN JINGKANG  
  选自 期刊  European Journal of Organic Chemistry;  卷期  2012年-28;  页码  5585-5594  
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[摘要]A new practical method for the synthesis of tetracyclic pyrido[2',1':2,3]imidazo[5,1-a]isoquinolinium compounds by a Yb(OTf)3/AgOTf-catalyzed (Tf = triflate) three-component domino reaction was developed. Significantly, the strategy presents a straightforward and efficient approach to constructing a series of compounds with potent cytotoxic activities.

 
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