Catalytic Enantioselective N-Nitroso Aldol Reaction of gamma,delta-Unsaturated delta-Lactones

[摘要]：A catalytic asymmetric N-nitroso aldol reaction of gamma,delta-didehydro-delta-lactones with nitrosoarenes was achieved using chiral tin dibromide as the chiral precatalyst and sodium ethoxide as the base precatalyst in the presence of ethanol. Optically active alpha-hydroxyamino ketones with up to 99% ee were regioselectively obtained in moderate to high yields from various delta-aryl-substituted gamma,delta-didehydro-delta-valerolactones and o-substituted nitrosoarenes.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内