Highly Efficient Cs2CO3-Catalyzed 1,4-Addition of Me3SiCN to Enones with Water as the Additive

[摘要]：A facile and efficient 1,4-addition of Me3SiCN to enones has been achieved with perfect regioselectivity using Cs2CO3 as catalyst. Thus, with 0.5 mol% of Cs2CO3 and 4 equivalents of H2O as the additive excellent yields (81-99%) of beta-cyanoketones are obtained within one to five hours. Both aromatic and aliphatic enones are found suitable substrates for this protocol.

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