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[摘要]：The synthesis of substituted 1,8-diarylnaphthalenes is reported. A bis-Suzuki coupling strategy starting from 1,8-di-bromonaphthalene provides a useful and general route to the 1,8-diarylnaphthalene scaffold. In this context, N-heterocyclic benzhydrylamine ligands, in combination with PdCl2, were found to form especially efficient catalytic systems. The syn/anti ratios were determined in solution from their H-1 NMR spectra. Analysis of the molecular structure in the solid state for six new targets focused on deformation of the naphthalene core. The observed lack of planarity occurs as a result of several parameters, such as the nature and number of substituents, the substitution pattern as well as steric congestion and pi-stacking between cofacial rings. |
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