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BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

  作者 Ren, DC; Tu, HC; Kim, H; Wang, GX; Bean, GR; Takeuchi, O; Jeffers, JR; Zambetti, GP; Hsieh, JJD; Cheng, EHY  
  选自 期刊  Science;  卷期  2010年330-6009;  页码  1390-1393  
  关联知识点  
 

[摘要]Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in vivo evidence demonstrating an essential role of the proteins BID, BIM, and PUMA in activating B

 
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