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CONVENIENT SYNTHESIS OF 5,7-DICHLOROTHIAZOLO[5,4-d]PYRIMIDINE

  作者 SHU LIANHE; ALABANZA LADY MAE; GU CHEN  
  选自 期刊  Heterocycles;  卷期  2012年85-7;  页码  1721-+  
  关联知识点  
 

[摘要]A convenient synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine is reported. The condensation of ethyl isocyanoacetate and ethoxycarbonyl isothiocyanate selectively gave the key 5-aminothiazole intermediate in high yield under mild conditions. This intermediate was then converted to the target product in three steps.

 
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