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Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA

  作者 DeMuth, PC; Su, XF; Samuel, RE; Hammond, PT; Irvine, DJ  
  选自 期刊  ADVANCED MATERIALS;  卷期  2010年22-43;  页码  4851-4851  
  关联知识点  
 

[摘要]Multilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer selfassembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II-GFP-green).

 
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