Iron-Catalyzed Unexpected Easy Access to Stereodefined Trimethylsilyl Vinyl Ketenes

[摘要]：Stereodefined trimethylsilyl vinyl ketenes with polysubstitution have been synthesized highly regio- and stereoselectively via an iron-catalyzed reaction of 2-trimethylsilyl-2,3-allenoates with Grignard reagents in good to excellent yields. The reaction was believed to proceed via a conjugate addition and elimination mechanism. Applications of the products for the synthesis of stereodefined alpha-silyl-beta,gamma-unsaturated enones, a stereodefined triene, and polysubstituted phenols have been carefully demonstrated.

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