Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold

[摘要]：In an effort to develop effective antiamoebic agents, some hydrazones and azoles containing pyridyl moiety were synthesized and screened for in vitro antiamoebic activity against HM1 : IMSS strain of Entamoeba histolytica. Among all the compounds, only five compounds (1, 3, 5,9 and 11) were found to be better inhibitors of growth of E histolytica than the reference drug metronidazole. The cytotoxic studies of these compounds on human breast cancer MCF-7 cell line revealed that all the compounds were low-cytotoxic in the concentration range of 2.5-250 mu M. (C) 2012 Elsevier Masson SAS. All rights reserved.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内