Preparation of 5-Substituted 2-(2-Alkyl/aryl-1H-imidazol-4-yl)oxazoles and 5-Substituted 2-(2-Alkyl/arylthiazol-4-yl)oxazoles by Utilizing 5-Substituted 2-(2-Bromo-1,1-diethoxyethyl)oxazole as a Synthon

[摘要]：Synthetic access to oxazolyl-substituted heterocycles including oxazolylimidazoles, -thiazoles, and -oxazoles is gained from a masked a-halo ketone attached to the 2-position of the oxazole ring. 3-Bromo-2,2-diethoxy-N-(2-oxoalkyl)propionamides readily cyclize to generate the key 5-substituted 2-(2-bromo-1,1-diethoxyethyl)oxazole intermediate.

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