Copper-Catalyzed Tandem C-N Bond Formation Reaction: Selective Synthesis of 2-(Trifluoromethyl)benzimidazoles

[摘要]：A highly practical method for the Synthesis Of fluorinated benzimidazoles was developed by Cul/TMEDA-catalyzed cross-coupling reaction of N-(2-haloaryl)trifluoroacetimidoyl chlorides with primary amines. The present double amination process tolerates the presence of Cl, Br, or I substituent at the 2-position of the phenyl group.

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