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CONVENIENT ONE-POT SYNTHESIS OF 3-ARYL-2H-CHROMENE-4-CARBONITRILES VIA A TANDEM O-ALKYLATION-KNOEVENAGEL CONDENSATION

  作者 CHEN YANHONG; XIANG HAOYUE; XIE YUYUAN; YANG CHUNHAO  
  选自 期刊  Heterocycles;  卷期  2011年83-6;  页码  1355-1361  
  关联知识点  
 

[摘要]3-Aryl-2H-chromene-4-carbonitriles were synthesized through one-pot tandem reaction of easily available 2-(2-hydroxyphenyl)acetonitrile (1) and 2-bromo-1-arylethanones (2) under the condition of K(2)CO(3)/dioxane. These functionalized chromenes could be useful building-blocks for estrogen receptor ligands and other related heterocycles.

 
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