Lewis Base Assisted Bronsted Base Catalysis: Direct Asymmetric Allylic Alkylation of Indenes

[摘要]：A direct, asymmetric allylic alkylation of indenes withMoritaBaylisHillman (MBH) carbonates has been developed based on a Lewis base assisted Bronsted base catalysis strategy. This process is promoted by a modified cinchona alkaloid hydroquinidine (anthraquinone-1,4-diyl) diether [(DHQD)2AQN] and gives rise to multifunctional chiral indene derivatives with moderate to excellent enantioselectivities (5395% ee), albeit in low to modest yields (2771%).

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