Synthesis of Chiral Benzoxa(thia)zepine and Pyridoxazepine Derivatives Using Palladium-Catalyzed Intramolecular Aryl Amination Reaction

[摘要]：A palladium-catalyzed method employing different bulky biaryl phosphanes as ligands has been developed for the intramolecular amination of aryl bromides and iodides. A variety of aryl halide substrates have been aminated through the intramolecular pathway in good yield using different sugar-derived amines to give furo-benzoxa(thia)zepine and pyridoxazepine derivatives. The method is capable of furnishing chiral, enantiopure benzoxa(thia)zepines and pyridoxazepines of significant biological importance.

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