Synthesis of Tricyclic Lactams from Heterocyclic Imines

[摘要]：Starting from different heterocyclic imines, a large number of annulated tricyclic lactams were prepared in a two-step synthesis. First, methoxyamides with a phenyl ring in alpha- or beta-position were generated. Finally, these substrates were converted to valero- and caprolactams, respectively, via intramolecular Friedel-Crafts cyclization in the presence of a Lewis acid. Additionally, effects of substituent groups at the phenyl ring in the electrophilic aromatic substitution were investigated.

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