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Copper(I)-Catalyzed Intramolecular O-Arylation for the Synthesis of 2,3,4,9-Tetrahydro-1H-xanthen-1-ones with Low Loads of CuCl

  作者 SUDHEENDRAN KAVITHA; MALAKAR CHANDI C; CONRAD JUERGEN; BEIFUSS UWE  
  选自 期刊  Journal of Organic Chemistry;  卷期  2012年77-22;  页码  10194-10210  
  关联知识点  
 

[摘要]As little as 0.5 mol % CuCl is sufficient to catalyze the intramolecular O-arylation of easily accessible 2-(2-bromobenzyl)cyclohexane-1,3-diones to provide the corresponding 2,3,4,9-tetrahydro-1H-xanthen-1-ones with yields ranging from 83% to 99%.

 
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