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[摘要]:A facile method for the simple synthesis of tetracyclic indoloisoxazolidine frameworks from Baylis-Hillman derivatives through formation of nitrones in situ followed by an intramolecular [3+2]-dipolar cycloaddition reaction sequence is described. High regio- and stereoselectivity, excellent yields, together with the creation of two rings and three contiguous stereogenic centers including one all carbon quaternary center, are the salient features of the present method. |
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