Synthesis of Tunable Bisphosphine Ligands and Their Application in Asymmetric Hydrogenation of Quinolines.

[摘要]：A series of tunable axial chiral bisphosphine ligands have been synthesized from (S)-MeO-Biphep. The Ir complex of the MeO-PEG-supported ligand I [R1 = n-C12H25, R2 = MeO-PEG-(1600)] has been successfully applied in asym. hydrogenation of quinolines with up to 92% ee. The catalyst system is air-stable and recyclable.

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