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作者 |
Wennberg, AM; Stenquist, B; Stockfleth, E; Keohane, S; Lear, JT; Jemec, G; Mork, C; Christensen, E; Kapp, A; Solvsten, H; Talme, T; Berne, B; Forschner, T |
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[摘要]:Background. Organ transplant recipients on long-term immunosuppressive therapy are at increased risk of non-melanoma skin lesions. Repeated field photodynamic therapy using topical methyl aminolevulinate (MAL) may have potential as a preventive treatment.Methods. This open randomized, intrapatient, comparative, multicenter Study included 81 transplant recipients with 889 lesions (90% actinic keratoses (AK)]. In each patient, the study treatment was initially administered to one 50 cm(2) area on the face, scalp, neck, trunk, or extremities (n=476 lesions) twice (I week apart), with additional single treatments at 3, 9, and 15 months. On each occasion, the area was debrided gently and MAL cream (160 mg/g) applied for 3 hr, before illumination with noncoherent red light (630 mm, 37 J/cm(2)). The control, 50 cm(2) area (n=413 lesions) received lesion-specific treatment (83% cryotherapy) at baseline and 3, 9, and 15 months. Additionally, all visible lesions were given lesion-specific treatment 21 and 27 months in both treatment and control areas.Results. At 3 months, MAL photodynamic therapy significantly reduced the Occurrence of new lesions (65 vs. 103 lesions in the control area; P=0.01), mainly AK (46% reduction; 43 vs. 80; P=0.006). This effect was not significant at 27 months (253 vs. 312; P=0.06). Hypopigmentation, as assessed by the investigator, was less evident in the treatment than control areas (16% vs. 51% of patients; P<0.001) at 27 months.Conclusion. Our results suggest that repeated field photodynamic therapy using topical MAL may prevent new AK in transplant recipients although further studies are needed. |
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