Ligands with cycloalkane backbones Part 6; (1) A series of chiral 2-pyrazolyl-cyclohexan-1-ols: Synthesis, spectroscopic features and kinetic resolution

[摘要]：Nucleophilic ring opening of epoxycyclohexane with a variety of pyrazoles afforded racemic 2-pyrazolylcyclohexan-1-ols in high yields. The kinetic resolution of these 1,3-diamino alcohols was achieved by enantioselective acylation with isopropenyl acetate in the presence of lipase B from Candida antarctica and separation of the enantiomerically pure alcohol and the ester by either MPLC or crystallization.

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