An efficient large-scale synthesis of (R)-(-)-mevalonolactone using simple biological and chemical catalysts

[摘要]：Natural (R)-(-)-mevalonolactone (2) was synthesized in eight steps in 55% total yield and >99% ee employing an enantioconvergent chemoenzymatic route. In the key step, 2-benzyl-2-methyloxirane (+/-)-3 was deracemized on a large scale (10 g) using lyophilized cells of Nocardia EH1 and sulfuric acid. The product diol (S)-4 was isolated in 94% chemical yield and 94% optical purity.

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