PEG-tethered guanosine acetal conjugates for the enzymatic synthesis of modified RNA

[摘要]：A short and efficient synthetic route to guanosine monophosphate conjugates connected to a protected aldehyde group via a flexible polydisperse polyethylene glycol linker is described. These conjugates are enzymatically incorporated into RNA transcripts with 52% yield. The resulting aldehyde-modified RNA gave full conversion in the reaction with biotin hydrazide, demonstrating the utility of the method. (C) 2012 Elsevier Inc. All rights reserved.

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