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[摘要]：Chemical investigation of an extract of the marine sponge Axinyssa sp., collected from the South China Sea, led to the isolation and identification of two new sesquiterpene formamides, (4R*,5R*,10R*)4-formamidoeudesm-7-ene (1) and (4R*,5R*,7S*,10R*)-4-formamidoeudesman-11-ol (2), together with the known 4a-formamidogorgon-11-ene (3). Their structures were elucidated by spectroscopic methods, including 1D- and 2D-NMR spectroscopy, high-resolution ESI-TOF mass spectrometry, as well as X-ray single-crystal diffraction experiments. Possible biosynthetic pathways for 1-3 were also proposed. The human nasopharyngeal cancer cell line CNE-2, human cervical cancer cell line HeLa, and human normal liver cell line L02 were used to examine the cytotoxic activities of 1-3 in vitro. As the results, 1 showed significant cytotoxic activity against CNE-2, HeLa, and L02 cell lines with the IC50 values of 13.8, 7.5, and 38.0 mu g/ml, resp. |
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