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[摘要]：The cross-coupling reaction of aryl bromides and iodides with aliph. and arom. thiols catalyzed by palladium complexes of the bisphosphine ligand CyPF-tBu (I) is reported. Reactions occur in excellent yields, broad scope, high tolerance of functional groups, and with turnover nos. that exceed those of previous catalysts by 2 or 3 orders of magnitude. These couplings of bromo- and iodoarenes are more efficient than the corresponding reactions of chloroarenes and could be conducted with less catalyst loading and/or milder reaction conditions. Consequently, limitations regarding scope and functional group tolerance previously reported in the coupling of aryl chlorides are now overcome. |
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