[摘要]:Highly concise syntheses of (+)-macrosphelides A and B I (R = OH, R1 = H; RR1 = O, resp.) were accomplished in this study. The key feature of our synthetic route involved the direct three-carbon homologation of the readily available Weinreb amide II by the addn. of a trans-vinylogous ester anion equiv. and facile construction of the 16-membered macrolide skeleton of macrosphelides via an intramol. nitrile oxide-olefin cycloaddn. The syntheses of macrosphelides A and B were completed with a 30 and 20% overall yield, resp. This paper describes the details of our syntheses.