Anomalous behavior of pentacoordinate copper complexes of dimethylphenanthroline and derivatives of terpyridine ligands: Studies on DNA binding, cleavage and apoptotic activity

[摘要]：Copper(II) complexes with substituted terpyridine ligands, namely [Cu(itpy)(dmp)](NO3)(2) (1) and [Cu (PtPY)(dmP)](NO3)(2) (2) have been synthesized and characterized. The interaction of the complexes with CT-DNA has been explored using spectroscopic techniques and viscosity. Complexes 1 and 2 bind in the grooves of DNA, interestingly 1 in the minor and 2 in the major groove. Both the complexes have been found to promote DNA cleavage: complex 1 through hydrolytic and 2 oxidative. Complexes 1 and 2 have been found to be cytotoxic and bring about apoptosis of human lung cancer cell line A549. (C) 2010 Elsevier Masson SAS. All rights reserved.

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