[摘要]：A facile and one-pot synthesis of a series of novel spiropyrrolidines/pyrrolizidines with beta-lactam substituent has been accomplished through 1,3-dipolar cycloaddition reaction of alkenyl esters derived from beta-lactam aldehyde as dipolarophile with the dipole azomethine ylide derived from 1,2- and 1,3-diketones and secondary amino acids. The synthesized compounds were evaluated for antimicrobial activities and found to exhibit relatively good antibacterial activity at lower concentration against four human bacterial pathogens. (C) 2010 Elsevier Masson SAS. All rights reserved.
